Ethanolamine → N-(2-Hydroxyethyl)-2-(isopropyl)-5-methylcyclohexanecarboxamide

HRID 1701498노트

반응식

HRID 1701498 반응식
[CH:1]1([CH3:13])[CH2:6][CH2:5][CH:4]([CH:7]([CH3:9])[CH3:8])[CH:3]([C:10](Cl)=[O:11])[CH2:2]1.[CH2:14]([CH2:16][NH2:17])[OH:15]>C(Cl)(Cl)Cl>[OH:15][CH2:14][CH2:16][NH:17][C:10]([CH:3]1[CH:4]([CH:7]([CH3:9])[CH3:8])[CH2:5][CH2:6][CH:1]([CH3:13])[CH2:2]1)=[O:11]

참가 물질

4

반응물 2

HCID 700EthanolamineHCID 13734319Cyclohexanecarbonyl chloride, 5-methyl-2-(1-methylethyl)-

생성물 1

HCID 3016102N-(2-Hydroxyethyl)-2-(isopropyl)-5-methylcyclohexanecarboxamide

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

A solution of p-menth-3-oyl chloride prepared as in Example 1 (4.0 g., 0.020 moles) in chloroform (30 ml.) was added dropwise to a stirred solution of ethanolamine (3 g., 0.043 moles) in chloroform (50 ml.). The reaction mixture becomes warm, goes cloudy and finally a yellow oil starts to separate out. After stirring for 2 hours at room temperature the mixture was poured into water. The organic layer was separated, washed with dilute H2SO4, and dried (MgSO4). Removal of the solvent left a viscous oil (3.8 g.). This was distilled under vacuum to yield N-(2-hydroxyethyl)-p-menthane-3-carboxamide as a colourless very viscous oil, b.p. 160°/01. mm.

후처리

  1. temperatureThe reaction mixture becomes warm
  2. customfinally a yellow oil starts to separate out
  3. additionwas poured into water
  4. customThe organic layer was separated
  5. washwashed with dilute H2SO4
  6. dry with materialdried (MgSO4)
  7. customRemoval of the solvent
  8. waitleft a viscous oil (3.8 g.)
  9. distillationThis was distilled under vacuum

출처 및 근거

ORD 기록
ord-6363817d4fd446539126530a8eeefaa1
출처 데이터셋
uspto-grants-1980_03
특허 번호
US04193936

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