Acetamide, N-(2,4-dimethyl-5-nitrophenyl)- → Acetamide, N-(5-amino-2,4-dimethylphenyl)-

HRID 1702117

반응식

HRID 1702117 반응식
[CH3:1][C:2]1[C:7]([NH:8][C:9]([CH3:11])=[O:10])=[CH:6][C:5]([N+:12]([O-])=O)=[C:4]([CH3:15])[CH:3]=1.[H][H].[S]>C(O)C.[Ni]>[CH3:15][C:4]1[C:5]([NH2:12])=[CH:6][C:7]([NH:8][C:9]([CH3:11])=[O:10])=[C:2]([CH3:1])[CH:3]=1

참가 물질

6

반응물 3

HCID 112848Acetamide, N-(2,4-dimethyl-5-nitrophenyl)-HCID 5362487SulfurHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 104605Acetamide, N-(5-amino-2,4-dimethylphenyl)-

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

2,4-Dimethyl-5-nitroacetanilide (20.8 g., 100 mmole) in ethanol (400 ml.) was reduced over Raney nickel at about 45 psi of hydrogen gas. After the hydrogen uptake was complete, the mixture was deactivated with elementary sulfur, filtered, and the filtrate was evaporated under reduced pressure to give the product as a solid, m.p. 163°-164° C.

후처리

  1. filtrationfiltered
  2. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-df332bd22928459b9d6d0a925c87e2e5
출처 데이터셋
uspto-grants-1983_04
특허 번호
US04380464

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