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Dicyclohexylcarbodiimide → 2-Propanone, O-(1-oxo-2-(4-(4-(trifluoromethyl)phenoxy)pheoxy)propyl)oxime

HRID 1702223
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HRID 1702223 반응식
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:21]=[CH:20][C:6]([O:7][C:8]2[CH:19]=[CH:18][C:11]([O:12][CH:13]([CH3:17])[C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[CH3:24][C:25](=[N:27]O)[CH3:26].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[F:1][C:2]([F:22])([F:23])[C:3]1[CH:4]=[CH:5][C:6]([O:7][C:8]2[CH:19]=[CH:18][C:11]([O:12][CH:13]([CH3:17])[C:14]([O:16][N:27]=[C:25]([CH3:26])[CH3:24])=[O:15])=[CH:10][CH:9]=2)=[CH:20][CH:21]=1
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참가 물질

5

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 67180Acetone, oximeHCID 181206Trifop

생성물 1

HCID 30367722-Propanone, O-(1-oxo-2-(4-(4-(trifluoromethyl)phenoxy)pheoxy)propyl)oxime

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

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온도
40 °C

실험 절차

After 15 g of 2-[p-(p-trifluoromethylphenoxy)phenoxy]-propionic acid are suspended in 20 ml of methylene chloride, 3.5 g of acetone oxime are added at room temperature. 9.8 g of dicyclohexylcarbodiimide, in 10 ml of methylene chloride, are then added dropwise over a period of 10 minutes as the temperature increases to about 40° C. The reaction mixture is then stirred at room temperature for 2 hours and filtered. The filtrate is evaporated to dryness on a rotary evaporator to yield acetone O-[2-[p-(p-trifluoromethylphenoxy)phenoxy]propionyl]-oxime, nD20 : 1.5212.

후처리

  1. filtrationfiltered
  2. customThe filtrate is evaporated to dryness on a rotary evaporator

출처 및 근거

ORD 기록
ord-1a38bfe14a824de4afb59d0d40dbfa8f
출처 데이터셋
uspto-grants-1983_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04380661

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