Cysteamine Hydrochloride → 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole

HRID 1702357노트

반응식

[CH3:1][N:2]([CH2:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10]O)[N:9]=1)[CH3:3].S(Cl)(Cl)=O.C[N:17]([CH2:19][C:20]1[S:21]C=C(CCl)N=1)C.Cl.NCCS>>[CH3:1][N:2]([CH2:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:21][CH2:20][CH2:19][NH2:17])[N:9]=1)[CH3:3]

참가 물질

반응물 4

HCID 9082Cysteamine Hydrochloride

HCID 24386Thionyl Chloride

HCID 1838020(2-((Dimethylamino)methyl)thiazol-4-yl)methanol

HCID 1967272N-{[4-(chloromethyl)-1,3-thiazol-2-yl]methyl}-N,N-dimethylamine

생성물 1

HCID 109773182-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole

실험 절차

When 2-dimethylaminomethyl-4-hydroxymethylthiazole [prepared in Step D] is reacted with thionyl chloride and the resultant 2-dimethylaminomethyl-4-chloromethylthiazole is reacted with an equimolar amount of cysteamine hydrochloride and two equivalents of base according to the general procedure of Example 33, Step D, the title compound is thereby produced.

출처 및 근거

ORD 기록: ord-ba38ef6383ed42a39943acef80f983c8
출처 데이터셋: uspto-grants-1983_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04380639

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