Methane → Carbamimidothioic acid(3-methyl-2-quinoxalinyl)ester, hydrochloride
반응식
[Cl:1][C:2]1[C:11]([CH3:12])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.C.[NH2:14][C:15]([NH2:17])=[S:16]>CC(C)=O>[ClH:1].[CH3:12][C:11]1[C:2]([S:16][C:15](=[NH:14])[NH2:17])=[N:3][C:4]2[C:9]([N:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2참가 물질
5
실험 절차
2-Chloro-3-methylquinoxaline (10.72 g., 0.06 mole) was dissolved in 150 ml. of acetone, treated with Norit and filtered. The filtrate was added to 4.56 g. (0.06 mole) of thiourea in 150 ml. acetone. The solution was stirred at reflux under nitrogen for 2 hours. The precipitate which began to form after 5 minutes, was filtered while the reaction mixture was hot. The solid was collected, washed with hot acetone and dried to give 11.85 g. of a pink solid, m.p. 156°-157° C.
후처리
- filtrationfiltered
- additionThe filtrate was added to 4.56 g
- temperatureat reflux under nitrogen for 2 hours
- customto form after 5 minutes
- filtrationwas filtered while the reaction mixture
- customThe solid was collected
- washwashed with hot acetone
- customdried
- customto give 11.85 g
출처 및 근거
- ORD 기록
- ord-4f4a18a7a7104b0787f29fc49657dc86
- 출처 데이터셋
- uspto-grants-1982_09
- 특허 번호
- US04349674
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