Tetrahydrofuran → 6-Chloro-5-fluoro-2-(2-fluoro-4-trimethylsilanyl-phenylamino)-nicotinic acid

HRID 170290노트

반응식

[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:14][Si:15]([N-:16][Si:17]([CH3:18])([CH3:19])[CH3:20])([CH3:21])[CH3:22].[Cl:23][c:24]1[c:25]([C:26](=[O:27])[OH:28])[cH:29][c:30]([F:34])[c:31]([Cl:33])[n:32]1.[F:1][c:2]1[c:3]([NH2:12])[cH:4][cH:5][c:6]([Si:8]([CH3:9])([CH3:10])[CH3:11])[cH:7]1.[Li+:13]>>[F:1][c:2]1[c:3]([NH:12][c:24]2[c:25]([C:26](=[O:27])[OH:28])[cH:29][c:30]([F:34])[c:31]([Cl:33])[n:32]2)[cH:4][cH:5][c:6]([Si:8]([CH3:9])([CH3:10])[CH3:11])[cH:7]1