Benzylamine → Diethyl 3-benzylamino-2-pentenedioate

HRID 1702912

반응식

HRID 1702912 반응식
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][CH2:10][O:11][C:12]([CH2:14][C:15]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])=O)=[O:13]>C1(C)C=CC=CC=1>[CH2:10]([O:11][C:12](=[O:13])[CH:14]=[C:15]([NH:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:9]

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 66045Diethyl acetonedicarboxylate

생성물 1

HCID 70353029Diethyl 3-benzylamino-2-pentenedioate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Benzylamine (89.1 g, 0.83 moles) is added over 10 minutes to a suspension of 5 A powdered molecular sieves (270 g) and diethyl 1,3-acetonedicarboxylate (160 g) (0.79 moles) in 350 ml toluene (external cooling applied to control exotherm). The suspension is stirred at room temperature for 14-17 hours and then filtered to provide 2. The filter cake is washed with three portions of toluene. The combined filtrates may be used as is in the subsequent ketene reaction.

후처리

  1. filtrationfiltered
  2. customto provide 2
  3. washThe filter cake is washed with three portions of toluene
  4. customas is in the subsequent ketene reaction

출처 및 근거

ORD 기록
ord-c258c59034db4cb6ad900f9b2918ab39
출처 데이터셋
uspto-grants-1982_09
특허 번호
US04349687

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