Hydrochloric Acid → 4-({[4-(Benzyloxy)phenyl]methyl}amino)benzoic acid

HRID 1703080노트

반응식

HRID 1703080 반응식
[CH2:1]([O:8][C:9]1[CH:27]=[CH:26][C:12]([CH2:13][NH:14][C:15]2[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].Cl>C(O)C.O>[CH2:1]([O:8][C:9]1[CH:27]=[CH:26][C:12]([CH2:13][NH:14][C:15]2[CH:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[CH:24][CH:25]=2)=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13079673Ethyl 4-({[4-(benzyloxy)phenyl]methyl}amino)benzoate

생성물 1

HCID 130796724-({[4-(Benzyloxy)phenyl]methyl}amino)benzoic acid

시약·촉매·용매 1

HCID 19096565Water ethanol용매

실험 절차

A mixture of 10 g. of ethyl p-[p-(benzyloxy)benzylamino]benzoate (prepared as described in Example 11) 10 g. of potassium hydroxide and 200 ml. of ethanol-water (9:1) are refluxed for 4.5 hours. While hot, the mixture is acidified with concentrated hydrochloric acid. Dilution with water and filtration gives tan crystals which are recrystallized from glacial acetic acid to give off-white crystals, m.p. 206°-208° C.

후처리

  1. additionA mixture of 10 g
  2. filtrationDilution with water and filtration
  3. customgives tan crystals which
  4. customare recrystallized from glacial acetic acid
  5. customto give off-white crystals, m.p. 206°-208° C.

출처 및 근거

ORD 기록
ord-12397f677470406295a1c14bbe0cc084
출처 데이터셋
uspto-grants-1982_09
특허 번호
US04350822

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