Benzocaine → Benzoic acid, 4-[[(4-methoxyphenyl)methyl]amino]-, ethyl ester

HRID 1703081노트

반응식

HRID 1703081 반응식
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][CH:3]=1.CN(C)P(N(C)C)(N(C)C)=O.Cl[CH2:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=1>O>[CH3:33][O:32][C:29]1[CH:30]=[CH:31][C:26]([CH2:25][NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:11][CH:12]=2)=[CH:27][CH:28]=1

참가 물질

5

반응물 3

HCID 2337BenzocaineHCID 12679HexamethylphosphoramideHCID 699934-Methyloxybenzyl chloride

생성물 1

HCID 4435805Benzoic acid, 4-[[(4-methoxyphenyl)methyl]amino]-, ethyl ester

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 33 g. of ethyl p-aminobenzoate, 100 ml. of hexamethylphosphoramide and 15.7 g. of p-(chloromethyl)anisole are heated at 100°-110° C. for 22 hours. The solution is chilled, diluted with 60 ml. of water, chilled, filtered and the solid washed with ethanol and with water to give yellow crystals. Recrystallization from ethanol gives pale yellow crystals, m.p. 128°-130° C.

후처리

  1. additionA mixture of 33 g
  2. temperatureThe solution is chilled
  3. additiondiluted with 60 ml
  4. filtrationfiltered
  5. washthe solid washed with ethanol and with water
  6. customto give yellow crystals
  7. customRecrystallization from ethanol
  8. customgives pale yellow crystals, m.p. 128°-130° C.

출처 및 근거

ORD 기록
ord-fb881b98d18c486d9784975c4cd9d082
출처 데이터셋
uspto-grants-1982_09
특허 번호
US04350822

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