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Hydrochloric Acid → 4-[(7-Phenylheptyl)amino]benzoic acid

HRID 1703096
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반응식

HRID 1703096 반응식
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]2[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].C(O)C.O.Cl>O>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]2[CH:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[CH:24][CH:25]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13079667Ethyl 4-[(7-phenylheptyl)amino]benzoateHCID 19096565Water ethanol

생성물 1

HCID 130796664-[(7-Phenylheptyl)amino]benzoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 5 g. of ethyl p-[(7-phenylheptyl)amino]benzoate (prepared as described in Example 34), 5 g. of KOH and 50 ml. of ethanol-water (9:1) is refluxed for 3.5 hours. The mixture is acidified while hot with concentrated hydrochloric acid, diluted with H2O, chilled and filtered. The solid is washed with H2O to give off-white crystals, m.p. 123°-126° C. Recrystallization from ethanol gives tan crystals, m.p. 123.5°-125° C.

후처리

  1. additionA mixture of 5 g
  2. temperaturechilled
  3. filtrationfiltered
  4. washThe solid is washed with H2O
  5. customto give off-white crystals, m.p. 123°-126° C
  6. customRecrystallization from ethanol
  7. customgives tan crystals, m.p. 123.5°-125° C.

출처 및 근거

ORD 기록
ord-50a35f36ed764817bfb2e77556110a4c
출처 데이터셋
uspto-grants-1982_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04350822

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