Sodium Hydroxide → HCID 12897098, 화합물

HRID 1703307노트

반응식

HRID 1703307 반응식
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[CH:8]=[C:9]([C:12]([O:14]CCO)=[O:13])[NH:10][CH:11]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>CC(C)=O>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[CH:8]=[C:9]([C:12]([OH:14])=[O:13])[NH:10][CH:11]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 20400896HCID 20400896, 화합물

생성물 1

HCID 12897098HCID 12897098, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

2-Hydroxyethyl 4-(4-chlorophenoxy)pyrrole-2-carboxylate (400 mg.) was dissolved in 10 ml. of acetone and 10 ml. of 1 N sodium hydroxide and left to stand at room temperature for approximately 16 hours. Acetone was evaporated in vacuo, the aqueous residue was acidified with conc. hydrochloric acid and crystalline product (320 mg.) recovered by filtration. Recrystallization from ether/hexane of 400 mg. of product prepared in this manner afforded purified 4-(4-chlorophenoxy)pyrrole-2-carboxylic acid (234 mg., m.p. 188°-190° C., m/e 237).

후처리

  1. customAcetone was evaporated in vacuo
  2. filtrationrecovered by filtration
  3. customRecrystallization from ether/hexane of 400 mg
  4. customof product prepared in this manner
  5. customafforded
  6. custompurified 4-(4-chlorophenoxy)pyrrole-2-carboxylic acid (234 mg., m.p. 188°-190° C., m/e 237)

출처 및 근거

ORD 기록
ord-65084bbaf8964bce9015382fddc4f4a0
출처 데이터셋
uspto-grants-1982_09
특허 번호
US04351843

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