Piperidine → 6-Pentyl-6-methyl-2-oxo-1,4-oxathiane-3-acetic acid

HRID 1703810노트

반응식

HRID 1703810 반응식
C[O:2][C:3](=[O:19])[CH2:4][CH:5]([C:16]([OH:18])=[O:17])[S:6][CH2:7][C:8](O)([CH3:14])[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].O=S(Cl)Cl.N1CCCCC1>C(Cl)(Cl)Cl>[CH2:9]([C:8]1([CH3:14])[O:17][C:16](=[O:18])[CH:5]([CH2:4][C:3]([OH:2])=[O:19])[S:6][CH2:7]1)[CH2:10][CH2:11][CH2:12][CH3:13]

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 24386Thionyl ChlorideHCID 544848136-Hydroxy-3-hydroxycarbonyl-6-methyl-4-thiaundecanoic acid methyl ester

생성물 1

HCID 227607726-Pentyl-6-methyl-2-oxo-1,4-oxathiane-3-acetic acid

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

2.7 g of 6-hydroxy-3-hydroxycarbonyl-6-methyl-4-thiaundecanoic acid methyl ester and 1.25 g of SOCl2 are stirred for 2 hours in 40 ml of chloroform at room temperature. The mixture is boiled briefly. After cooling, 0.5 ml of piperidine, dissolved in 20 ml of chloroform is added thereto. The resultant mixture is further stirred for 1 hour at 30°. After the usual working up, 6-pentyl-6-methyl-2-oxo-1,4-oxathiane-3-acetic acid is obtained.

후처리

  1. temperatureAfter cooling
  2. additionis added

출처 및 근거

ORD 기록
ord-1ebe0ee7dd4b4508baebe09bfa0e7f6c
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04125622

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