3-(4-Fluorophenoxy)propionic acid → 1-Propanol, 2-(4-fluorophenoxy)-

HRID 1704139노트

반응식

HRID 1704139 반응식
B#B.[F:3][C:4]1[CH:15]=[CH:14][C:7]([O:8][CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:6][CH:5]=1>O1CCCC1>[F:3][C:4]1[CH:15]=[CH:14][C:7]([O:8][CH:9]([CH3:13])[CH2:10][OH:11])=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 38721403-(4-Fluorophenoxy)propionic acidHCID 6328200Diboron

생성물 1

HCID 104647301-Propanol, 2-(4-fluorophenoxy)-수율 92.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To 95 ml of 1 Molar diborane in tetrahydrofuran is added 10.2 g of 2-(p-fluorophenoxy)propionic acid in 100 ml of tetrahydrofuran. The mixture is stirred at room temperature for 20 hrs. and poured onto 600 g of ice. The mixture is extracted with chloroform and the chloroform extracts dried (MgSO4). The solvent is removed under vacuum and the residual liquid distilled to give 8.7 g of colorless liquid.

후처리

  1. extractionThe mixture is extracted with chloroform
  2. dry with materialthe chloroform extracts dried (MgSO4)
  3. customThe solvent is removed under vacuum
  4. distillationthe residual liquid distilled

출처 및 근거

ORD 기록
ord-10c47979acf6498c85bb2e4b89255ffb
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04125732

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