Sodium Hydroxide → Sodium 2-amino-3-benzoyl-alpha-methylphenylacetate Hydrate

HRID 1704335

반응식

HRID 1704335 반응식
[C:1]([C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:17]=1[NH:16][C:15](=[O:18])[CH:14]2[CH3:19])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:20].[Na+:21]>O>[OH2:8].[NH2:16][C:17]1[C:9]([C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:10][CH:11]=[CH:12][C:13]=1[CH:14]([CH3:19])[C:15]([O-:20])=[O:18].[Na+:21]

참가 물질

4

반응물 2

HCID 14798Sodium Hydroxide2회HCID 129012437-Benzoyl-3-methyl-1,3-dihydro-2H-indol-2-one

생성물 1

HCID 70591625Sodium 2-amino-3-benzoyl-alpha-methylphenylacetate Hydrate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A suspension of 9 g. (0.036 mole) of 7-benzoyl-3-methylindolin-2-one in 100 ml. of 3N sodium hydroxide was refluxed for 18 hrs. under nitrogen. The mixture was filtered and stripped under water pump vacuum to yield a gummy mixture of sodium hydroxide, water, and product. The mixture was triturated with boiling isopropanol and filtered. The isopropanol solution was cooled and filtered to separate the bright yellow product. The product weighed 4.0 g. and melted at 218° C. (dec.)

후처리

  1. additionA suspension of 9 g
  2. filtrationThe mixture was filtered
  3. customto yield
  4. customThe mixture was triturated with boiling isopropanol
  5. filtrationfiltered
  6. temperatureThe isopropanol solution was cooled
  7. filtrationfiltered
  8. customto separate the bright yellow product

출처 및 근거

ORD 기록
ord-364ae030771f49a889c74a71ed8c28e4
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04126635

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