Dimethyl Sulfoxide → 2-(p-Biphenylyl)-3-butyn-2-ol

HRID 1704719

반응식

HRID 1704719 반응식
[C:1]1([C:7]2[CH:12]=[CH:11][C:10](C(=O)C)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CS(C)=O.[OH2:20]>>[C:7]1([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=1[C:2]([OH:20])([C:1]#[CH:6])[CH3:3]

참가 물질

4

반응물 3

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 71134-Acetylbiphenyl

생성물 1

HCID 867348962-(p-Biphenylyl)-3-butyn-2-ol

실험 절차

To a solution of 46.6 g of p-phenylacetophenone in 250 ml. of dimethyl sulfoxide, there is added 65.5 g of lithium acetylide - ethylene diamine complex. After 18 hours at room temperature, the mixture is poured on 2 liters of iced water. The initial oil solidifies on standing, is filtered off and recrystallized from 150 mlof isopropyl alcohol to give 2-(p-biphenylyl)-3-butyn-2-ol, mp 75°-80° C.

후처리

  1. filtrationThe initial oil solidifies on standing, is filtered off
  2. customrecrystallized from 150 mlof isopropyl alcohol

출처 및 근거

ORD 기록
ord-27bacc7435c84a7e8e9ce5c037570e74
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04127658

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