Phenol → 8-furfuryl-5-phenyloxy-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine

HRID 1704761

반응식

HRID 1704761 반응식
N(C1C(C(OCC)=O)=CN=C2N(CC3OC=CC=3)N=CC=12)N.C(N1C2=NC=C(C(OCC)=O)C(NN)=C2C=N1)C.[CH2:41]([N:47]1[C:51]2[N:52]=[CH:53][C:54]3[C:55](=[O:63])[NH:56][C:57]4[N:58]([N:60]=[CH:61][N:62]=4)[C:59]=3[C:50]=2[CH:49]=[N:48]1)[C:42]1[O:46][CH:45]=[CH:44][CH:43]=1.[C:64]1(O)[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=1>C(O)C>[CH2:41]([N:47]1[C:51]2[N:52]=[CH:53][C:54]3[C:55]([O:63][C:64]4[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=4)=[N:56][C:57]4[N:58]([N:60]=[CH:61][N:62]=4)[C:59]=3[C:50]=2[CH:49]=[N:48]1)[C:42]1[O:46][CH:45]=[CH:44][CH:43]=1

참가 물질

6

반응물 4

HCID 996PhenolHCID 1623571-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl esterHCID 867354024-Hydrazino-1-furfurylpyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl esterHCID 1355938608-furfuryl-4H-pyrazolo-[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one

생성물 1

HCID 227585308-furfuryl-5-phenyloxy-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

By substituting 4-hydrazino-1-furfurylpyrazolo-[3,4-b]pyridine-5-carboxylic acid, ethyl ester for the 1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester in Example 1 a, 8-furfuryl-4H-pyrazolo-[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one is obtained. This compound is now processed as in Example 1 b and then as in Example 4, substituting phenol for the ethanol to obtain 8-furfuryl-5-phenyloxy-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo-[1,5-a]pyrimidine.

후처리

  1. customis obtained

출처 및 근거

ORD 기록
ord-116dd96379cd429e8faee956d7404e63
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04127655

연결된 노트

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