Water → 4-Oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylic Acid

HRID 1704811노트

반응식

HRID 1704811 반응식
[O:1]=[C:2]1[N:7]2[CH:8]=[CH:9][C:10]3[C:15]([C:6]2=[N:5][CH:4]=[C:3]1[C:16]([O:18]CC)=[O:17])=[CH:14][CH:13]=[CH:12][CH:11]=3.[OH-].[Na+].O>C(O)C>[O:1]=[C:2]1[N:7]2[CH:8]=[CH:9][C:10]3[C:15]([C:6]2=[N:5][CH:4]=[C:3]1[C:16]([OH:18])=[O:17])=[CH:14][CH:13]=[CH:12][CH:11]=3

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 13851097Ethyl 4-Oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate

생성물 1

HCID 227588274-Oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylic Acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of ethyl 4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (2.78 g., 0.010 mole), 1.0 N NaOH (15.0 ml.), H2O (40 ml.) and ethanol (30 ml.) was refluxed for 15 minutes. The mixture was filtered and the cooled filtrate acidified with 15.0 ml. of 1.0 N HCl to precipitate crude acid (2.36 g.), m.p. 193°-223°. Two recrystallizations from 2-methoxyethanol gave peach needles, m.p. 252°-253.5°.

후처리

  1. temperaturewas refluxed for 15 minutes
  2. filtrationThe mixture was filtered
  3. customof 1.0 N HCl to precipitate crude acid (2.36 g.), m.p. 193°-223°
  4. customTwo recrystallizations from 2-methoxyethanol
  5. customgave peach needles, m.p. 252°-253.5°

출처 및 근거

ORD 기록
ord-a59d824971bf4c57bb5dc76074e0fe98
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04127720

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