HCID 22758819, 화합물 → HCID 22758848, 화합물
반응식
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][N:9]3[C:16](=[O:17])[C:15]([C:18]([O:20]CC)=[O:19])=[CH:14][N:13]=[C:10]32)=[CH:5][CH:4]=1>Br>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][N:9]3[C:16](=[O:17])[C:15]([C:18]([OH:20])=[O:19])=[CH:14][N:13]=[C:10]32)=[CH:5][CH:4]=1참가 물질
3
실험 절차
A solution of ethyl 6,7-dihydro-10-methoxy-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (5.0 g., 0.0175 mole) in 48% hydrobromic acid (125 ml.) was refluxed for 4 hours. The solution was cooled and the yellow product collected, washed with water, and dissolved in warm 0.5 N NaOH (80 ml.). The basic solution was treated with decolorizing carbon, filtered and the filtrate acidified with hydrochloric acid. The precipitated material was washed on the filter successively with water, ethanol and acetone to give 3.5 g. (81% yield) of the title acid, m.p. 326°-327°.
후처리
- temperatureThe solution was cooled
- customthe yellow product collected