Benzyl Chloride → 4-Benzyloxy-alpha-ethyldesoxybenzoin

HRID 1706166노트

반응식

HRID 1706166 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH:10]([CH2:17][CH3:18])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:9])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].[CH2:25](Cl)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>C(O)C.O.[I-].[K+]>[CH2:25]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH:10]([CH2:17][CH3:18])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:9])=[CH:6][CH:7]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

참가 물질

7

반응물 3

HCID 7503Benzyl ChlorideHCID 10340Sodium CarbonateHCID 2272781-(4-Hydroxyphenyl)-2-phenylbutan-1-one

생성물 1

HCID 189765134-Benzyloxy-alpha-ethyldesoxybenzoin

시약·촉매·용매 3

HCID 4875Potassium Iodide촉매HCID 702Ethanol용매HCID 962Water용매

실험 절차

A mixture of 4-hydroxy-α-ethyldesoxybenzoin (44.5 g.), sodium carbonate (18.5 g.), potassium iodide (1.4 g.) and benzyl chloride (19 ml.) in ethanol (350 ml.) and water (50 ml.) was stirred and heated under reflux for 8 hours. The mixture was cooled, filtered and the residue washed with water to give 4-benzyloxy-α-ethyldesoxybenzoin (54.3 g.), m.p. 71° C.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 8 hours
  3. temperatureThe mixture was cooled
  4. filtrationfiltered
  5. washthe residue washed with water

출처 및 근거

ORD 기록
ord-528364d8dd7c4792bab41a8275fa4036
출처 데이터셋
uspto-grants-1980_06
특허 번호
US04206234

반응 노트

불러오는 중…