Triethyl phosphite → Diethyl 3-chloro-2-methylpropylphosphonate

HRID 1706170노트

반응식

Br[CH2:2][CH:3]([CH3:6])[CH2:4][Cl:5].[P:7]([O:14]CC)([O:11][CH2:12][CH3:13])[O:8][CH2:9][CH3:10]>>[Cl:5][CH2:4][CH:3]([CH3:6])[CH2:2][P:7](=[O:14])([O:11][CH2:12][CH3:13])[O:8][CH2:9][CH3:10]

참가 물질

반응물 2

HCID 31215Triethyl phosphite

HCID 955661-Bromo-3-chloro-2-methylpropane

생성물 1

HCID 20337215Diethyl 3-chloro-2-methylpropylphosphonate수율 57.2%

실험 절차

A mixture of 1-bromo-3-chloro-2-methylpropane (95 g.) and triethyl phosphite (61.4 g.) was heated to reflux for 5.5 hours with stirring and then excess 1-bromo-3-chloro-2-methylpropane was distilled off under reduced pressure to give oily diethyl 3-chloro-2-methylpropylphosphonate (48.3 g.).

후처리

temperaturewas heated
temperatureto reflux for 5.5 hours
distillationexcess 1-bromo-3-chloro-2-methylpropane was distilled off under reduced pressure

출처 및 근거

ORD 기록: ord-c55080848a19478180f97cf3fdb8e005
출처 데이터셋: uspto-grants-1980_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04206156

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