Benzoyl Peroxide → Diethyl [(1E)-3-bromoprop-1-en-1-yl]phosphonate

HRID 1706173노트

반응식

HRID 1706173 반응식
[CH:1](/[P:4](=[O:11])([O:8][CH2:9][CH3:10])[O:5][CH2:6][CH3:7])=[CH:2]\[CH3:3].[Br:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:12][CH2:3]/[CH:2]=[CH:1]/[P:4](=[O:11])([O:5][CH2:6][CH3:7])[O:8][CH2:9][CH3:10]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 5702572Diethyl (1E)-prop-1-en-1-ylphosphonate

생성물 1

HCID 5702525Diethyl [(1E)-3-bromoprop-1-en-1-yl]phosphonate수율 58.5%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

To a solution of diethyl trans-1-propenylphosphonate (32.04 g.) in carbon tetrachloride (320 ml.) were added N-bromosuccinimide (41.65 g.) and dibenzoylperoxide (2.8 g.). The reaction mixture was heated to reflux for 1.5 hours and stirred for 30 minutes under ice-cooling. Insoluble materials were removed off by filtration and the filtrate was concentrated under reduced pressure to give an oily residue (63.09 g.), which was subjected to a column chromatography on silicagel and eluted with chloroform. The eluates were evaporated to dryness under reduced pressure to give an oily diethyl 3-bromo-trans-1-propenylphosphonate (27.04 g.).

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 1.5 hours
  3. temperaturecooling
  4. customInsoluble materials were removed off by filtration
  5. concentrationthe filtrate was concentrated under reduced pressure
  6. customto give an oily residue (63.09 g.), which
  7. washeluted with chloroform
  8. customThe eluates were evaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-20ce39297641490bbb96e6488c05935b
출처 데이터셋
uspto-grants-1980_06
특허 번호
US04206156

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