Acetic Acid → 3-Phenyl-2-propen-1-yl acetate

HRID 1706280노트

반응식

HRID 1706280 반응식
BrC1C=CC=C[N+]=1C.[CH2:9]([OH:18])[CH:10]=[CH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[C:19](O)(=[O:21])[CH3:20].C(N(CCCC)CCCC)CCC>C(Cl)Cl>[C:19]([O:18][CH2:9][CH:10]=[CH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:21])[CH3:20]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 3083-Phenylprop-2-En-1-OlHCID 7622TributylamineHCID 8183862-Bromo-1-methylpyridinium

생성물 1

HCID 76603-Phenyl-2-propen-1-yl acetate수율 82%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a suspended CH2Cl2 (2 ml) solution of 2-bromo-1-methylpyridinium (720 mg, 2.4 mmol) was added a mixture of cinnamyl alcohol (268 mg, 2.0 mmol), acetic acid (120 mg, 2.0 mmol) and tri-n-butylamine (888 mg, 4.8 mmol) in CH2Cl2 (2 ml), and the resulting mixture was refluxed for 3 hours. After evaporation of the solvent, the residue was separated by silica gel column chromatography, and cinnamyl acetate was isolated in 82% yield.

후처리

  1. temperaturethe resulting mixture was refluxed for 3 hours
  2. customAfter evaporation of the solvent
  3. customthe residue was separated by silica gel column chromatography

출처 및 근거

ORD 기록
ord-fbbdbf7e4d28439f8c42c9a5d0606676
출처 데이터셋
uspto-grants-1980_06
특허 번호
US04206310

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