Methyl acetoacetate → 3-Furancarboxylic acid, 2,5-dimethyl-, methyl ester
반응식
[C:1]([O:7][CH3:8])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].C(O[CH:13]([CH3:16])[CH:14]=O)(=O)C>[Fe].CO>[CH3:8][O:7][C:1]([C:2]1[CH:14]=[C:13]([CH3:16])[O:4][C:3]=1[CH3:5])=[O:6]참가 물질
5
반응 조건
- 온도
- 20 °C
실험 절차
27 parts by weight of anhydrous iron-III chloride are added to a solution of 116 parts by weight of methyl acetoacetate in 120 parts by weight of methanol and thereafter 149 parts by weight of 85.5 percent strength α-acetoxypropionaldehyde are added dropwise, sufficiently slowly that the temperature does not rise above 37° C. The mixture is stirred overnight at room temperature (20° C.), is then boiled for 2 hours, and, when it has cooled, is worked up as described in Example 1. Distillation gives 116.6 parts by weight of 2,5-dimethylfuran-3-carboxylic acid methyl ester.
후처리
- customdoes not rise above 37° C
- waitis then boiled for 2 hours
- temperaturewhen it has cooled
- distillationDistillation
출처 및 근거
- ORD 기록
- ord-30828b858241423fa202fd29149a5bd0
- 출처 데이터셋
- uspto-grants-1980_06
- 특허 번호
- US04207243
반응 노트
불러오는 중…