Methyl acetoacetate → 3-Furancarboxylic acid, 2,5-dimethyl-, methyl ester

HRID 1706338

반응식

HRID 1706338 반응식
[C:1]([O:4][CH:5]([CH3:8])[CH:6]=O)(=O)[CH3:2].[C:9]([O:15][CH3:16])(=[O:14])[CH2:10]C(C)=O>[Fe].CO>[CH3:16][O:15][C:9]([C:10]1[CH:6]=[C:5]([CH3:8])[O:4][C:1]=1[CH3:2])=[O:14]

참가 물질

5

반응물 2

HCID 7757Methyl acetoacetateHCID 907282-(Acetyloxy)propanal

생성물 1

HCID 802483-Furancarboxylic acid, 2,5-dimethyl-, methyl ester

시약·촉매·용매 2

HCID 23925Iron촉매HCID 887Methanol용매

실험 절차

27 parts by weight of iron-III chloride and 149 parts by weight of 85.5 percent strength α-acetoxypropionaldehyde are added to a solution of 116 parts by weight of methyl acetoacetate in 120 parts by weight of methanol at a rate such that the mixture rises to the boil. The methanol is distilled off under atmospheric pressure and the product is then distilled under reduced pressure. 106.2 parts by weight of 2,5-dimethylfuran-3-carboxylic acid methyl ester, of boiling point 89° C./20 mbar, are obtained.

후처리

  1. distillationThe methanol is distilled off under atmospheric pressure
  2. distillationthe product is then distilled under reduced pressure

출처 및 근거

ORD 기록
ord-c8642babbd0f4c62b60da3f1892d1dd2
출처 데이터셋
uspto-grants-1980_06
특허 번호
US04207243

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