Hydrochloric Acid → HCID 15099437, 화합물

HRID 1706380노트

반응식

HRID 1706380 반응식
[CH2:1]([N:8]1[C:12]([CH2:13][C:14]([OH:16])=[O:15])=[C:11]([Cl:17])[N:10]=[C:9]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH2:25](O)[CH3:26]>>[CH2:1]([N:8]1[C:12]([CH2:13][C:14]([O:16][CH2:25][CH3:26])=[O:15])=[C:11]([Cl:17])[N:10]=[C:9]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 1920381-Benzyl-4-chloro-2-phenylimidazole-5-acetic acid

생성물 1

HCID 15099437HCID 15099437, 화합물

실험 절차

In 100 ml of ethanol was dissolved 6.53 g of 1-benzyl-2-phenyl-4-chloroimidazole-5-acetic acid and under ice-cooling, hydrogen chloride was introduced until saturation. The solution was further stirred at room temperature overnight. The reaction mixture was concentrated to dryness under reduced pressure and the concentrate was run onto a column of 200 g silica gel, elution being carried out with benzene-chloroform (1:1). By the above procedure was obtained 2.28 g of 1-benzyl-2-phenyl-4-chloro-5-ethoxycarbonylmethylimidazole as crude crystals, which were then recrystallized from diethyl ether-hexane. Colorless needles, m.p. 72°-73° C.

후처리

  1. temperatureunder ice-cooling
  2. concentrationThe reaction mixture was concentrated to dryness under reduced pressure
  3. washthe concentrate was run onto a column of 200 g silica gel, elution

출처 및 근거

ORD 기록
ord-a124f841e7b4426d9cd426dc67a49c77
출처 데이터셋
uspto-grants-1980_06
특허 번호
US04207324

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