Ethyl orthoformate → 6-Phenyl-1,2,4-triazolo[4,3-a]pyrimidine

반응식

[NH:1]([C:3]1[N:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][N:4]=1)[NH2:2].[CH:15](OCC)(OCC)OCC>>[C:9]1([C:6]2[CH:7]=[N:8][C:3]3[N:4]([CH:15]=[N:2][N:1]=3)[CH:5]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

반응물 2

HCID 31214Ethyl orthoformate

HCID 141699362-Hydrazino-5-phenylpyrimidine

생성물 1

HCID 203333416-Phenyl-1,2,4-triazolo[4,3-a]pyrimidine

실험 절차

A mixture of 2.5 g. of 2-hydrazino-5-phenylpyrimidine and 25 ml. of triethyl orthoformate is heated for 16 hours under reflux. The material that separates is collected and crystallized from ethanol to give 1.5 g. of the product of the Example, m.p. 231° C.

후처리

additionA mixture of 2.5 g
temperatureunder reflux
customThe material that separates is collected
customcrystallized from ethanol
customto give 1.5 g

출처 및 근거

ORD 기록: ord-9a4192171b444a14a381a1fef4bfd061
출처 데이터셋: uspto-grants-1980_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04209621

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