4'-Methoxyacetophenone → 3-(Dimethylamino)-1-(4-methoxyphenyl)prop-2-en-1-one

HRID 1707058노트

반응식

HRID 1707058 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:11])[CH3:10])=[CH:5][CH:4]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[CH3:14][N:15]([CH3:17])[CH:16]=[CH:10][C:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[O:11]

참가 물질

3

반응물 2

HCID 74764'-MethoxyacetophenoneHCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 7224023-(Dimethylamino)-1-(4-methoxyphenyl)prop-2-en-1-one

실험 절차

A mixture of 25 g. of p-methoxyacetophenone and 25 ml. of dimethylformamide dimethylacetal is refluxed for 9 hours. Evaporation gives an oil which crystallized on the addition of hexane. Recrystallization from methylene chloride and hexane gives the desired compound, m.p. 92°-95° C.

후처리

  1. additionA mixture of 25 g
  2. customEvaporation
  3. customgives an oil which
  4. customcrystallized on the addition of hexane
  5. customRecrystallization from methylene chloride and hexane

출처 및 근거

ORD 기록
ord-76fb4e6b26464811b9cbda1ab5e7fe4f
출처 데이터셋
uspto-grants-1980_06
특허 번호
US04209621

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