Hydrochloric Acid → Piperazin-1-yl-pyridin-4-yl-methanone

HRID 1707631노트

반응식

HRID 1707631 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[O:8])=[CH:3][CH:2]=1.Cl.C([O-])([O-])=O.[K+].[K+]>C(Cl)Cl>[N:1]1[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[O:8])=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 15289251HCID 15289251, 화합물

생성물 1

HCID 876553Piperazin-1-yl-pyridin-4-yl-methanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The title material was synthesized from the title product of Example 26 (1.3 g, 4.46 mmol) by the method described in Example 25, except that the title free base was generated by treatment of its HCl salt with 0.5N K2CO3 in CH2Cl2. The CH2Cl2 solution was dried over Na2SO4 and all solvent removed under reduced pressure to provide 333 mg of the title free base. This material was used without further purification.

후처리

  1. dry with materialThe CH2Cl2 solution was dried over Na2SO4
  2. customall solvent removed under reduced pressure
  3. customto provide 333 mg of the title free base
  4. customThis material was used without further purification

출처 및 근거

ORD 기록
ord-8f1c74933a8048a0a466d1baba5ba83c
출처 데이터셋
uspto-grants-1994_10
특허 번호
US05354747

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