Water → 1-Ethynyl-4-pentylbenzene

HRID 1707887노트

반응식

HRID 1707887 반응식
CC(O)(C)[C:3]#[C:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[CH:7][CH:6]=1.[H-].[Na+].O>C1(C)C=CC=CC=1>[CH2:11]([C:8]1[CH:7]=[CH:6][C:5]([C:4]#[CH:3])=[CH:10][CH:9]=1)[CH2:12][CH2:13][CH2:14][CH3:15]

참가 물질

5

반응물 3

HCID 962WaterHCID 24758Sodium hydrideHCID 189600502-Methyl-4-(4-pentylphenyl)-3-butyn-2-ol

생성물 1

HCID 27751311-Ethynyl-4-pentylbenzene수율 78.3%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
60 °C

실험 절차

3-Methyl-1-(4'-pentylphenyl)-1-butyne-3-ol (82 g) was dissolved in toluene (900 ml) under nitrogen atmosphere, and then sodium hydride (60% in paraffin liquid; 5.6 g) was added thereto, followed by stirring at 60° C. for 6 hours. The reaction solution was poured into water (500 ml), and extracted with chloroform, followed by washing with water three times. After distilling off toluene and chloroform, the resultant was distilled under reduced pressure (b.p. 85° to 90° C./3 mmHg) to give 4-pentylphenylacetylene (48 g).

후처리

  1. extractionextracted with chloroform
  2. washby washing with water three times
  3. distillationAfter distilling off toluene and chloroform
  4. distillationthe resultant was distilled under reduced pressure (b.p. 85° to 90° C./3 mmHg)

출처 및 근거

ORD 기록
ord-38f07c5ccb884bc3b6fdd552c381312b
출처 데이터셋
uspto-grants-1994_10
특허 번호
US05356558

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