Miconazole Nitrate → Miconazole

HRID 1708995

반응식

HRID 1708995 반응식
[CH:1]1[C:6]([Cl:7])=[CH:5][C:4]([Cl:8])=[C:3]([CH2:9][O:10][CH:11]([C:18]2[CH:19]=[CH:20][C:21]([Cl:25])=[CH:22][C:23]=2[Cl:24])[CH2:12][N:13]2[CH:17]=[N:16][CH:15]=[CH:14]2)[CH:2]=1.[N+]([O-])(O)=O.N1(C([O-])=O)CCCC1=O>C(O)C.O>[CH:1]1[C:6]([Cl:7])=[CH:5][C:4]([Cl:8])=[C:3]([CH2:9][O:10][CH:11]([C:18]2[CH:19]=[CH:20][C:21]([Cl:25])=[CH:22][C:23]=2[Cl:24])[CH2:12][N:13]2[CH:17]=[N:16][CH:15]=[CH:14]2)[CH:2]=1

참가 물질

5

반응물 2

HCID 68553Miconazole NitrateHCID 21917698HCID 21917698, 화합물

생성물 1

HCID 4189Miconazole수율 0.6%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

0.06 g of miconazole nitrate are dissolved in 4.5 g of ethyl alcohol and 0.44 g of water, and mixed with 5.0 g of 2% chitosonium pyrrolidone carboxylate in 90:10 water/alcohol, giving a clear, colorless solution (0.6% miconazole). This lotion is useful in the treatment of a variety of topical fungal infections, including Athlete's foot.

출처 및 근거

ORD 기록
ord-4fb1cdf27e4d4d26985af65cb578bf48
출처 데이터셋
uspto-grants-1990_08
특허 번호
US04946870

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