Benzoyl chloride → 1-Benzoyl-5-(octyloxy)pyrrolidin-2-one

HRID 1709180노트

반응식

HRID 1709180 반응식
C([Li])CCC.[CH2:6]([O:14][CH:15]1[NH:19][C:18](=[O:20])[CH2:17][CH2:16]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[C:21](Cl)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>CCCCCC.O1CCCC1>[C:21]([N:19]1[CH:15]([O:14][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH2:16][CH2:17][C:18]1=[O:20])(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

6

반응물 3

HCID 7412Benzoyl chlorideHCID 15696565HCID 15696565, 화합물HCID 178418339Butyllithium

생성물 1

HCID 30779561-Benzoyl-5-(octyloxy)pyrrolidin-2-one

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매2회HCID 8058Hexane용매

실험 절차

16.5 cm3 of a 15% solution of butyllithium in hexane is added at -60° C. to 5.3 g of 5-n-octyloxy pyrrolidin-2-one in solution in 200 cm3 of tetrahydrofuran. After agitation for 20 minutes at -60° C., then, while maintaining these conditions, a solution of 3.5 g of benzoyl chloride in 50 cm3 of tetrahydrofuran is added. Agitation is continued while allowing to return to ambient temperature. After concentration and chromatography on silica (eluent: toluene-ethyl acetate 8-2), 4.2 g of the product sought is obtained.

후처리

  1. temperaturewhile maintaining these conditions
  2. customto return to ambient temperature
  3. concentrationAfter concentration and chromatography on silica (eluent: toluene-ethyl acetate 8-2), 4.2 g of the product
  4. customsought is obtained

출처 및 근거

ORD 기록
ord-132333b5d7f04286a9cbc2b70fd7d8f4
출처 데이터셋
uspto-grants-1990_08
특허 번호
US04948804

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