Potassium Iodide → 3-Methyl-5-(trifluoromethyl)benzyl bromide
반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH3:10])[CH:6]=[C:7]([CH3:9])[CH:8]=1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[Br:31]N1C(=O)CCC1=O.[I-].[K+]>C1C=CC=CC=1>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:4]=[C:5]([CH:6]=[C:7]([CH3:9])[CH:8]=1)[CH2:10][Br:31]참가 물질
6
실험 절차
A solution of 5-trifluoromethyl-m-xylene (3.4 g) and dibenzoyl peroxide (0.25 g) in 100 ml of benzene at reflux is treated with N-bromosuccinimide (4.4 g) in portions. The mixture is heated until a negative potassium iodide test is obtained. The reaction mixture is cooled and concentrated in vacuo. The residue is triturated with n-hexane and the solids are removed by filtration. The filtrate is evaporated to give the oily crude benzyl bromide.
후처리
- customis obtained
- temperatureThe reaction mixture is cooled
- concentrationconcentrated in vacuo
- customThe residue is triturated with n-hexane
- customthe solids are removed by filtration
- customThe filtrate is evaporated
출처 및 근거
- ORD 기록
- ord-f975c6610df74bc09f0f214ed0cb421c
- 출처 데이터셋
- uspto-grants-1990_08
- 특허 번호
- US04950673
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