Pyrazole → 1-(2,6-Dichloro-4-nitrophenyl)-pyrazole

HRID 1709694

반응식

HRID 1709694 반응식
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.[H-].[Na+].[Cl:8][C:9]1[CH:10]=[C:11]([N+:17]([O-:19])=[O:18])[CH:12]=[C:13]([Cl:16])[C:14]=1F>CN(C=O)C>[Cl:8][C:9]1[CH:10]=[C:11]([N+:17]([O-:19])=[O:18])[CH:12]=[C:13]([Cl:16])[C:14]=1[N:1]1[CH:5]=[CH:4][CH:3]=[N:2]1

참가 물질

5

반응물 3

HCID 1048PyrazoleHCID 24758Sodium hydrideHCID 765541,3-Dichloro-2-fluoro-5-nitrobenzene

생성물 1

HCID 230365521-(2,6-Dichloro-4-nitrophenyl)-pyrazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매3회

실험 절차

Pyrazole (1.43 g, 21,0 mmol) in 3 ml of DMF is added dropwise at RT to a suspension of sodium hydride (50%; 1.0 g, 21.0 mmol) in 10 ml of DMF. The mixture is stirred at RT for 30 min., after which it is added dropwise at 5° over a period of 30 min. to a solution of 3,5-dichloro-4-fluoronitrobenzene (3.0 g, 15.0 mmol) in 20 ml of DMF. After reaction is complete, the reaction mixture is quenched with water and extracted with ethyl acetate. The combined organic layers are washed with water and with brine and dried to give a yellow solid, 1-(2,6-dichloro-4-nitrophenyl)-pyrazole.

후처리

  1. customAfter reaction
  2. customthe reaction mixture is quenched with water
  3. extractionextracted with ethyl acetate
  4. washThe combined organic layers are washed with water and with brine
  5. customdried

출처 및 근거

ORD 기록
ord-e9cf5a8757d7446da8ef330c5a36ec4c
출처 데이터셋
uspto-grants-1990_08
특허 번호
US04950678

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