Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4-Morpholineacetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Methyl Morpholinoacetate | HCID 1268178 | — |
| 용매 | Sodium hydroxide tetrahydrofuran | HCID 20445995 | — |
| 생성물 | 4-Morpholineacetic acid | HCID 438968 | 90.3% |
반응 단계
A solution of methyl N-morpholinoacetate (0.85 g, 5.3 mmol) in 1:1 5N NaOH/THF (10 ml) was stirred at 50° C. for 1 h then neutralized to pH 3 with 6N HCl and concentrated. The yellowish solid was diluted with 1:1 MeOH/CH2Cl2 (25 ml), filtered to remove inorganic salts, and concentrated. The dilution, filtration and concentration were repeated to give morpholin-4-yl-acetic acid (695 mg, 90%) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07790747B2 |
| 출처 데이터셋 | uspto-grants-2010_09 |
| ORD ID | ord-c839efddee6145ae97f0e0a9e044b0e9 |
| 출처 메모 | uspto-grants-2010_09 |