Acetic Acid → Ziprasidone Hydrochloride

HRID 1711975

반응식

HRID 1711975 반응식
[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]4[CH:19]=[C:20]5[CH2:28][C:26](=[O:27])[NH:25][C:21]5=[CH:22][C:23]=4[Cl:24])[CH2:12][CH2:11]3)[C:5]=2[CH:6]=1.C(O)(=O)C.[ClH:33].O>C(O)(C)C>[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][C:18]4[CH:19]=[C:20]5[CH2:28][C:26](=[O:27])[NH:25][C:21]5=[CH:22][C:23]=4[Cl:24])[CH2:14][CH2:15]3)[C:5]=2[CH:6]=1.[ClH:33]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 962WaterHCID 60854Ziprasidone

생성물 1

HCID 219099Ziprasidone Hydrochloride

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
47.5 °C

실험 절차

Ziprasidone (5 g) and 50 mL of acetic acid were placed into a round bottom flask and heated to 45-50° C. Added was 25 mL of aqueous hydrochloric acid slowly to the mixture over 20 min. Then the reaction mixture was refluxed. Water (10 mL) was added, followed by addition of 50 mL of Isopropanol. The reaction mass was cooled to 50° C. and distilled off the solvent completely under vacuum. The material formed was scratched from the flask.

후처리

  1. additionAdded
  2. customover 20 min
  3. temperatureThen the reaction mixture was refluxed
  4. temperatureThe reaction mass was cooled to 50° C.
  5. distillationdistilled off the solvent completely under vacuum
  6. customThe material formed

출처 및 근거

ORD 기록
ord-36d1abf674464e1b903451edb8e95ec6
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07790886B2

연결된 노트

불러오는 중…