Butaclamol → Dopamine

HRID 1712869

반응식

HRID 1712869 반응식
C[N:2]1[CH2:12][C@H:11](C2C=CC=CC=2)[C:10]2[CH:9]=[C:8]([OH:19])[C:7](Cl)=[CH:6][C:5]=2CC1.CC([C@]1([OH:47])C[C@H]2N(C[C@H]3C4C2=CC=CC=4CCC2C=CC=CC3=2)CC1)(C)C>>[NH2:2][CH2:12][CH2:11][C:10]1[CH:5]=[CH:6][C:7]([OH:47])=[C:8]([OH:19])[CH:9]=1

참가 물질

3

반응물 2

HCID 37461ButaclamolHCID 3036864R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol

생성물 1

HCID 681Dopamine

실험 절차

HEK cells were transfected with DNA encoding D1-NLS-GFP (2 micrograms), and D1-WT (6 micrograms) for 48 hours. These cells were treated 6 hrs after transfection with SCH-23390 (10 micromolar), or (+)butaclamol (10 micromolar). The medium containing antagonist was changed at 6, 22, 30 and 42 hours after transfection. Control cells received no antagonist treatment.

후처리

  1. additionThe medium containing antagonist
  2. customwas changed at 6, 22, 30 and 42 hours

출처 및 근거

ORD 기록
ord-a3f9fc04036e44f4afbc9730448073af
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07794955B2

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