Hydrochloric Acid → N-(5-acetylpyridin-3-yl)acetamide

HRID 1712919노트

반응식

HRID 1712919 반응식
C([O:3][C:4]([C:6]1[CH:7]=[C:8]([NH:12][C:13](=[O:15])[CH3:14])[CH:9]=[N:10][CH:11]=1)=[CH2:5])C.Cl.C([O-])(O)=O.[Na+]>CC(C)=O>[C:4]([C:6]1[CH:7]=[C:8]([NH:12][C:13](=[O:15])[CH3:14])[CH:9]=[N:10][CH:11]=1)(=[O:3])[CH3:5]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 59463096N-[5-(1-ethoxyvinyl)pyridin-3-yl]acetamide

생성물 1

HCID 59463126N-(5-acetylpyridin-3-yl)acetamide수율 42.1%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of N-[5-(1-ethoxyvinyl)pyridin-3-yl]acetamide (2.4 mmol) in acetone (9 mL) was added 1N HCl (1 mL). The reaction mixture was allowed to stir at rt overnight and then basified with sat NaHCO3 and extracted with EtOAc. The organic solutions were combined, dried over Na2SO4, filtered, and concentrated. The residue was purified by column chromatography to give N-(5-acetylpyridin-3-yl)acetamide (0.180 g, 42%) as a white solid. LCMS: (FA) ES+ 179.1.

후처리

  1. extractionextracted with EtOAc
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customThe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-656848e6eb94422299f0f751b9247ddd
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07795249B2

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