Di-tert-butyl dicarbonate → Tert-butyl (2-bromo-5-methoxybenzyl)carbamate
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH2:10][NH2:11].[O:12](C(OC(C)(C)C)=O)[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=O>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH2:10][NH:11][C:13](=[O:12])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17]참가 물질
4
실험 절차
To a solution of 1-(2-bromo-5-methoxyphenyl)methanamine (3.2 mmol) in DCM (15 mL) was added BOC2O (3.2 mmol). The reaction mixture was allowed to stir at rt overnight and then concentrated. The residue was purified by column chromatography to give tert-butyl (2-bromo-5-methoxybenzyl)carbamate (3.1 mmol, 95%).
후처리
- concentrationconcentrated
- customThe residue was purified by column chromatography
출처 및 근거
- ORD 기록
- ord-70f8d574887042aabeef4e1eeace8023
- 출처 데이터셋
- uspto-grants-2010_09
- 특허 번호
- US07795249B2
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