Hydrochloric Acid → 2-cyclopentyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine hydrochloride

HRID 1713169노트

반응식

HRID 1713169 반응식
[CH:1]1([N:6]2[CH:21]=[C:9]3[CH2:10][N:11](C(OC(C)(C)C)=O)[CH2:12][CH2:13][C:8]3=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:22]>O1CCOCC1>[ClH:22].[CH:1]1([N:6]2[CH:21]=[C:9]3[CH2:10][NH:11][CH2:12][CH2:13][C:8]3=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57356886tert-butyl 2-cyclopentyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate

생성물 1

HCID 574499462-cyclopentyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a solution of tert-butyl 2-cyclopentyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate (720 g, 2.47 mmol) in dioxane (5 mL) is added 4N HCl in dioxane (5 mL, 20 mmol) and the mixture is stirred at rt overnight. The solvent is removed and the residue is washed with ether to give the title compound as a white solid. MS (M+1): 192.1

후처리

  1. customThe solvent is removed
  2. washthe residue is washed with ether

출처 및 근거

ORD 기록
ord-4bbb66c662c046418a3691e47d2b29df
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07795262B2

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