1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → n-(6-Amino-1-ethyl-2,4-dioxo(1,3-dihydropyrimidin-5-yl))(1-{[3-(trifluoromethyl)phenyl]methyl} pyrazol-4-yl)carboxamide

HRID 1713191

반응식

HRID 1713191 반응식
[NH2:1][C:2]1[C:3](=[O:12])[NH:4][C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[F:13][C:14]([F:31])([F:30])[C:15]1[CH:16]=[C:17]([CH2:21][N:22]2[CH:26]=[C:25]([C:27](O)=[O:28])[CH:24]=[N:23]2)[CH:18]=[CH:19][CH:20]=1.Cl.CN(C)CCCN=C=NCC>CO>[NH2:8][C:7]1[N:6]([CH2:9][CH3:10])[C:5](=[O:11])[NH:4][C:3](=[O:12])[C:2]=1[NH:1][C:27]([C:25]1[CH:24]=[N:23][N:22]([CH2:21][C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([C:14]([F:31])([F:13])[F:30])[CH:16]=2)[CH:26]=1)=[O:28]

참가 물질

5

반응물 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 114927411-(3-(Trifluoromethyl)benzyl)-1H-pyrazole-4-carboxylic acidHCID 219163605,6-Diamino-1-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

생성물 1

HCID 21916363n-(6-Amino-1-ethyl-2,4-dioxo(1,3-dihydropyrimidin-5-yl))(1-{[3-(trifluoromethyl)phenyl]methyl} pyrazol-4-yl)carboxamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a mixture of 5,6-diamino-1-ethyl-1,3-dihydropyrimidine-2,4-dione (2 g, 11.76 mmol) and 1-{[3-(trifluoromethyl)phenyl]methyl}pyrazole-4-carboxylic acid (3.5 g, 12.94 mmol) in methanol (50 ml) was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (2.47 g, 12.94 mmol), and the reaction mixture was stirred for 16 hours at room temperature. Solvent was removed under reduced pressure, and the residue was washed with water and methanol. The product was dried under vacuum to provide N-(6-amino-1-ethyl-2,4-dioxo(1,3-dihydropyrimidin-5-yl))(1-{[3-(trifluoromethyl)phenyl]methyl}pyrazol-4-yl)carboxamide, a compound of formula (16).

후처리

  1. customSolvent was removed under reduced pressure
  2. washthe residue was washed with water and methanol
  3. customThe product was dried under vacuum

출처 및 근거

ORD 기록
ord-4d7de872bf9849b2adf6f93de4a76121
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07795268B2

연결된 노트

불러오는 중…