Formaldehyde → 2,3,4-Trihydroxy-5-(pyrrolidin-1-ylmethyl)benzaldehyde

HRID 1714698

반응식

HRID 1714698 반응식
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:6]=O.[OH:8][C:9]1[C:16]([OH:17])=[C:15]([OH:18])[CH:14]=[CH:13][C:10]=1[CH:11]=[O:12]>C(O)C>[OH:8][C:9]1[C:16]([OH:17])=[C:15]([OH:18])[C:14]([CH2:6][N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:13][C:10]=1[CH:11]=[O:12]

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 31268PyrrolidineHCID 750642,3,4-Trihydroxybenzaldehyde

생성물 1

HCID 592358752,3,4-Trihydroxy-5-(pyrrolidin-1-ylmethyl)benzaldehyde

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

17.1 g (0.24 mol) of pyrrolidine were added to 19.2 g (0.24 mol) of a 37% aqueous formaldehyde solution in 140 ml of ethanol. Then 25.0 g (0.16 mol) of 2,3,4-trihydroxybenzaldehyde were added thereto. The reaction mixture was refluxed for one hour, developing a dark brown color. After cooling, a beige-brown solid precipitated out, which was filtered out and dried.

후처리

  1. temperatureThe reaction mixture was refluxed for one hour
  2. temperatureAfter cooling
  3. customa beige-brown solid precipitated out
  4. filtrationwhich was filtered out
  5. customdried

출처 및 근거

ORD 기록
ord-67d55e0849d94d16add0d304b338eac5
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07799096B2

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