Imidazole → 1-(Tert-butyldimethylsilyloxy)-4-iodobut-2-yne

HRID 1714711노트

반응식

HRID 1714711 반응식
[Si:1]([O:8][CH2:9][C:10]#[C:11][CH2:12]O)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].N1C=CN=C1.[I:19]I.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClCCl>[Si:1]([O:8][CH2:9][C:10]#[C:11][CH2:12][I:19])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

참가 물질

6

반응물 4

HCID 795ImidazoleHCID 807IodineHCID 11776TriphenylphosphineHCID 54618454-((Tert-butyldimethylsilyl)oxy)but-2-yn-1-ol

생성물 1

HCID 111414181-(Tert-butyldimethylsilyloxy)-4-iodobut-2-yne수율 71.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1-(tert-Butyldimethylsilyloxy)-but-2-yn-4-ol (63, 4.0 g, 19.96 mmol), imidazole (1.80 g, 26.45 mmol), iodine (6.58 g, 25.95 mmol) and triphenylphosphine (6.80 g, 25.95 mmol) are treated in 100 ml dichloromethane according to J. Robertson et al. J. Chem. Soc., Perkin Trans. 1, 3389-3369, 2000. Work-up yields 4.42 g (71%) of a colourless oil. The product is used directly in the next step.

출처 및 근거

ORD 기록
ord-632d369607ef46129d6d7e30a88e646b
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07799524B2

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