Methyl iodide → HCID 23155891, 화합물
반응식
O1CCC[CH2:2]1.[CH3:6][N:7]1[C:16](=[O:17])[C:15]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=2[N:9]=[C:8]1[S-:18].[K+].CI>CN(C)C=O>[CH3:6][N:7]1[C:16](=[O:17])[C:15]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=2[N:9]=[C:8]1[S:18][CH3:2]참가 물질
5
실험 절차
To a mixture of 10 ml of tetrahydrofuran and 5 ml of dimethylformamide, 340 mg of potassium 3-methyl-4-oxo-3,4,5,6,7,8-hexahydroquinazoline-2-thiolate was added, followed by addition of 210 mg of methyl iodide and an overnight's stirring at room temperature. The solution was concentrated, to which chloroform was added, followed by washing with saturated brine and drying over anhydrous magnesium sulfate. Distilling the solvent off under reduced pressure, 310 mg (quantitative) of 3-methyl-2-methylthio-5,6,7,8-tetrahydro-3H-quinazolin-4-one was obtained.
후처리
- additionwas added
- concentrationThe solution was concentrated, to which chloroform
- additionwas added
- washby washing with saturated brine
- dry with materialdrying over anhydrous magnesium sulfate
- distillationDistilling the solvent off under reduced pressure
출처 및 근거
- ORD 기록
- ord-c954db947ff84596914c90f8b74c76de
- 출처 데이터셋
- uspto-grants-2010_09
- 특허 번호
- US07799775B2
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