Methanol → Methyl 4-nitrobenzoate

HRID 1715243

반응식

HRID 1715243 반응식
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[N+](=[CH2:15])=[N-].CO>C1(C)C=CC=CC=1>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:8]([O:10][CH3:15])=[O:9])=[CH:11][CH:12]=1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 887MethanolHCID 61084-Nitrobenzoic AcidHCID 9550Diazomethane

생성물 1

HCID 12083Methyl 4-nitrobenzoate

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

4-Nitrobenzoic acid (5 g; 29.92 mmol; 1 eq.) is dissolved in toluene (37.5 ml). Timethylsilyl diazomethane in toluene and MeOH (1/1)(45 ml; 2 M; 89.76 mmol; 3 eq.) is added dropwise. The solution is stirred at rt for 2 h. Solvents are removed affording methyl 4-nitrobenzoate as a yellow powder (5.42 g; 100%).

후처리

  1. customSolvents are removed

출처 및 근거

ORD 기록
ord-6600c12735224b1bbc62555e5a9a6cb7
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07799814B2

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