Benzoyl chloride → HCID 836063, 화합물
반응식
[NH2:1][C:2]1[C:3]([Cl:8])=[N:4][CH:5]=[CH:6][CH:7]=1.[C:9](Cl)(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>N1C=CC=CC=1>[Cl:8][C:3]1[C:2]([NH:1][C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:7][CH:6]=[CH:5][N:4]=1참가 물질
4
실험 절차
4.57 g 3-amino-2-chloropyridine (36 mmol) and 30 mL pyridine were mixed in an ice bath. 5.0 g benzoyl chloride (36 mol) was then added. After return to room temperature and reaction for 4 hr, the reaction was quenched by water. After extraction three times by ethyl acetate, an ethyl acetate layer was collected and washed by 1M HCl solution. After drying, filtration, concentration, and purification by silicon-gel column, 7.21 g solid was obtained, with a yield of 88%.
후처리
- customAfter return to room temperature and reaction for 4 hr
- customthe reaction was quenched by water
- extractionAfter extraction three times by ethyl acetate
- customan ethyl acetate layer was collected
- washwashed by 1M HCl solution
- customAfter drying
- filtrationfiltration, concentration, and purification by silicon-gel column
출처 및 근거
- ORD 기록
- ord-ec26ed74f77e4255aa9122612271721d
- 출처 데이터셋
- uspto-grants-2010_09
- 특허 번호
- US07799918B2
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