Succinic anhydride → N-(3-Carboxypropanoyl)-N-methyl-glycine Benzyl Ester

HRID 1716

반응식

HRID 1716 반응식
[CH2:1]([O:8][C:9](=[O:13])[CH2:10][NH:11][CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:14]1(=[O:20])[O:19][C:17](=[O:18])[CH2:16][CH2:15]1>C1(C)C=CC=CC=1>[CH2:1]([O:8][C:9](=[O:13])[CH2:10][N:11]([C:14](=[O:20])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])[CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 7922Succinic anhydrideHCID 7019103Benzyl 2-(methylamino)acetate

생성물 1

HCID 19356295N-(3-Carboxypropanoyl)-N-methyl-glycine Benzyl Ester수율 86.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of sarcosine benzyl ester (3.0 g, 30.7 mmol) and succinic anhydride (5.5 g, 30.7 mmol) in toluene (75 mL) was heated to reflux for 3 h, cooled, filtered, and the filtrate was concentrated. The residue was taken up in 5% aqueous sodium carbonate and extracted with ethyl acetate. The aqueous phase was adjusted to pH 3 with concentrated hydrochloric using Congo Red paper and extracted with ethyl acetate. The organic phase was washed with water, dried (magnesium sulfate) and concentrated to yield the title compound (7.4 g, 67.5%): TLC Rf 0.48 (silica, 9:1:1 dichloromethane:methanol:formic acid).

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 3 h
  3. temperaturecooled
  4. filtrationfiltered
  5. concentrationthe filtrate was concentrated
  6. extractionextracted with ethyl acetate
  7. concentrationwith concentrated hydrochloric
  8. extractionextracted with ethyl acetate
  9. washThe organic phase was washed with water
  10. dry with materialdried (magnesium sulfate)
  11. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ccae603003f14fca9668b5a8da6d0d4d
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05726192

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