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Sodium Hydroxide → 3-(1-{5-[6-(4-Methyl-pyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}piperidin-4-yl)propionic acid

HRID 1716524
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HRID 1716524 반응식
C[O:2][C:3](=[O:31])[CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[S:13][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:24]4[CH:29]=[C:28]([CH3:30])[CH:27]=[CH:26][N:25]=4)[N:18]=3)=[CH:15][N:16]=2)[CH2:8][CH2:7]1.[OH-].[Na+]>O1CCCC1.CO>[CH3:30][C:28]1[CH:27]=[CH:26][N:25]=[C:24]([NH:23][C:19]2[N:18]=[C:17]([C:14]3[S:13][C:12]([N:9]4[CH2:8][CH2:7][CH:6]([CH2:5][CH2:4][C:3]([OH:31])=[O:2])[CH2:11][CH2:10]4)=[N:16][CH:15]=3)[CH:22]=[CH:21][CH:20]=2)[CH:29]=1
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참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 587069463-(1-{5-[6(4-Methyl-pyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}piperidin-4-yl)propionic acid methyl ester

생성물 1

HCID 441765793-(1-{5-[6-(4-Methyl-pyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}piperidin-4-yl)propionic acid수율 59%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028
Tetrahydrofuran
용매

실험 절차

To a mixed solution of 3-(1-{5-[6-(4-methyl-pyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}piperidine-4-)propionic acid methyl ester (250 mg, 0.57 mmol) obtained in Step 3 in tetrahydrofuran (5 ml) and methanol (5 ml), 4N sodium hydroxide (1.5 ml, 6.0 mmol) was added and the mixture was stirred at room temperature for 12 hours. The concentrate obtained by concentrating the reaction solution in vacuo was neutralized with 0.1N hydrochloric acid, and the precipitated solid was collected by filtration, washed with water and the title compound (142 mg, 59%) was obtained.

후처리

  1. customThe concentrate obtained
  2. concentrationby concentrating the reaction solution in vacuo
  3. filtrationthe precipitated solid was collected by filtration
  4. washwashed with water

출처 및 근거

ORD 기록
ord-1222bb7885754c168674955ec2b93ed4
출처 데이터셋
uspto-grants-2010_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07803801B2

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