Hydrochloric Acid → HCID 68513196, 화합물

HRID 1716596노트

반응식

HRID 1716596 반응식
C(OC(=O)[NH:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[CH2:13][CH:12]([C:17]([N:19]1[CH2:24][CH2:23][CH:22]([N:25]3[C:29]4[CH:30]=[CH:31][C:32]([CH3:34])=[CH:33][C:28]=4[N:27]=[C:26]3[C:35]([OH:38])([CH3:37])[CH3:36])[CH2:21][CH2:20]1)=[O:18])[CH2:11]2)(C)(C)C.Cl>O1CCOCC1>[NH2:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[CH2:13][CH:12]([C:17]([N:19]1[CH2:20][CH2:21][CH:22]([N:25]3[C:29]4[CH:30]=[CH:31][C:32]([CH3:34])=[CH:33][C:28]=4[N:27]=[C:26]3[C:35]([OH:38])([CH3:36])[CH3:37])[CH2:23][CH2:24]1)=[O:18])[CH2:11]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68513435HCID 68513435, 화합물

생성물 1

HCID 68513196HCID 68513196, 화합물수율 95%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of (2-{4-[2-(1-hydroxy-1-methyl-ethyl)-5-methyl-benzoimidazol-1-yl]-piperidine-1-carbonyl}-indan-5-yl)-carbamic acid tert-butyl ester (266 mg, 0.49 mmol) in dioxane (2 mL) was added 4 M HCl (2 ml). After the addition was complete, the reaction mixture was stirred for 1 hour. The solvent mixture was quenched with saturated NaHCO3 and extracted with ethyl acetate, the extracts was dried over Na2SO4 and concentrated to afford (5-amino-indan-2-yl)-{4-[2-(1-hydroxy-1-methyl-ethyl)-5-methyl-benzoimidazol-1-yl]-piperidin-1-yl}-methanone (200 mg 95%) as a white solid.

후처리

  1. additionAfter the addition
  2. customThe solvent mixture was quenched with saturated NaHCO3
  3. extractionextracted with ethyl acetate
  4. dry with materialthe extracts was dried over Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-26dd5e4fa5284e19aff5ac4109290e92
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803816B2

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