2,6-Diaminopyridine → N-(6-Aminopyridin-2-yl)-2,6-dichlorobenzamide

HRID 1716905

반응식

HRID 1716905 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[N:3]=1.[Cl:9][C:10]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:11]=1[C:12](Cl)=[O:13]>O1CCOCC1>[NH2:8][C:4]1[N:3]=[C:2]([NH:1][C:12](=[O:13])[C:11]2[C:10]([Cl:9])=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:19])[CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 88612,6-DiaminopyridineHCID 783922,6-Dichlorobenzoyl chloride

생성물 1

HCID 58997335N-(6-Aminopyridin-2-yl)-2,6-dichlorobenzamide수율 66.5%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Using a method similar to Preparation 48, using 2,6-diaminopyridine (2.6 g, 24 mmol), dioxane (75 mL), and 2,6-dichlorobenzoyl chloride (1.68 g, 8 mmol) (stir at 25° C. for 16 hr.) gives the title intermediate (1.5 g, 66% yield): mass spectrum (ion spray): m/z=282.0 (M+1)

후처리

  1. customsimilar to Preparation 48

출처 및 근거

ORD 기록
ord-2247df25414d4e02be621e20b8e3a9a1
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803813B2

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