Water → 1-[2-ethoxy-4-[(ethylamino)carbonyl]phenyl]-1H-1,2,3-Triazole-4-carboxylic acid

HRID 1717332노트

반응식

HRID 1717332 반응식
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([C:10]([NH:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][C:5]=1[N:15]1[CH:19]=[C:18]([C:20]([O:22]CC)=[O:21])[N:17]=[N:16]1)[CH3:2].[OH-].[Na+].O>C(O)C>[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([C:10]([NH:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][C:5]=1[N:15]1[CH:19]=[C:18]([C:20]([OH:22])=[O:21])[N:17]=[N:16]1)[CH3:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 68516073ethyl 1-{2-ethoxy-4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxylate

생성물 1

HCID 685156141-[2-ethoxy-4-[(ethylamino)carbonyl]phenyl]-1H-1,2,3-Triazole-4-carboxylic acid수율 77.1%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

To a solution of ethyl 1-{2-ethoxy-4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxylate (0.51 g) obtained in Example 131e) in ethanol (8 ml) was added 8N aqueous sodium hydroxide solution (0.39 ml), and the mixture was stirred at room temperature for 5 hr. Water was added to the reaction mixture, and ethanol was evaporated under reduced pressure. Water was added to the obtained aqueous solution and the mixture was washed with ethyl acetate. 1N Hydrochloric acid was added to acidify the aqueous solution. The deposited precipitate was collected by filtration, washed with water and air-dried to give the title compound as a white powder (0.36 g, 76%).

후처리

  1. customwas evaporated under reduced pressure
  2. additionWater was added to the obtained aqueous solution
  3. washthe mixture was washed with ethyl acetate
  4. addition1N Hydrochloric acid was added
  5. filtrationThe deposited precipitate was collected by filtration
  6. washwashed with water
  7. customair-dried

출처 및 근거

ORD 기록
ord-ad996ebaa3164c459bba85c107a38987
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803822B2

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